Keith W Ward Selected Research

besifloxacin

10/2010	Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.
8/2009	Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans.
11/2008	Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells.
1/2008	Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes.
6/2007	Nonclinical pharmacodynamics, pharmacokinetics, and safety of BOL-303224-A, a novel fluoroquinolone antimicrobial agent for topical ophthalmic use.

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Keith W Ward Research Topics

Disease

7	Inflammation (Inflammations) 01/2017 - 06/2007
5	Dry Eye Syndromes (Dry Eye Syndrome) 03/2012 - 09/2010
4	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2018 - 11/2008
3	Neoplasms (Cancer) 07/2014 - 09/2005
3	Infections 11/2008 - 06/2007
2	Hypoxia (Hypoxemia) 01/2016 - 05/2008
2	Atherosclerosis 09/2014 - 11/2002
2	Heart Failure 01/2014 - 11/2002
2	Type 2 Diabetes Mellitus (MODY) 01/2014 - 06/2013
2	Chronic Renal Insufficiency 01/2014 - 06/2013
2	Body Weight (Weight, Body) 03/2011 - 06/2004
2	Eye Diseases (Eye Disease) 01/2011 - 12/2009
2	Bacterial Conjunctivitis 10/2010 - 08/2009
2	Eye Infections 08/2009 - 01/2008
1	Friedreich Ataxia (Friedreich's Ataxia) 01/2019
1	Hyperglycemia 01/2017
1	Gliosis 01/2016
1	Hyperoxia 01/2016
1	Retinopathy of Prematurity (Retrolental Fibroplasia) 01/2016
1	Diabetic Nephropathies (Diabetic Nephropathy) 09/2014
1	Skin Diseases (Skin Disease) 07/2014
1	Dermatitis 05/2014
1	Erythema 05/2014
1	Skin Ulcer 05/2014
1	Necrosis 05/2014
1	Radiodermatitis 05/2014
1	Liver Diseases (Liver Disease) 07/2013
1	Obesity 06/2013
1	Albuminuria 10/2012
1	Body Weight Changes 03/2011
1	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 01/2011
1	Reperfusion Injury 11/2008
1	Vitreous Detachment (Posterior Vitreous Detachment) 06/2008
1	Hyperemia 05/2008
1	Phototoxic Dermatitis (Phototoxicity) 06/2007
1	Retinal Diseases 06/2007
1	Bone Resorption 03/2006
1	Renal Insufficiency (Renal Failure) 11/2002
1	Pulmonary Hypertension 11/2002

Drug/Important Bio-Agent (IBA)

5	TriterpenesIBA 01/2019 - 06/2013
5	AntioxidantsIBA 01/2018 - 02/2011
5	besifloxacin FDA Link 10/2010 - 06/2007
4	bardoxolone methylIBA 09/2014 - 10/2012
4	R- 1,1,1- trifluoro- 4- (5- fluoro- 2,3- dihydrobenzofuran- 7- yl)- 4- methyl- 2- (((2- methyl- 5- quinolyl)amino)methyl)pentan- 2- olIBA 03/2011 - 12/2009
3	omaveloxoloneIBA 01/2019 - 05/2014
3	oleananeIBA 01/2019 - 07/2013
2	Transcription Factors (Transcription Factor)IBA 01/2019 - 05/2014
2	Endothelins (Endothelin)IBA 01/2014 - 11/2002
2	LipidsIBA 06/2013 - 10/2012
2	Matrix Metalloproteinases (MMPs)IBA 03/2012 - 04/2011
2	CytokinesIBA 03/2012 - 04/2011
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 09/2010 - 12/2009
2	cloricromen (AD 6)IBA 08/2009 - 06/2007
2	Retinaldehyde (Retinal)IBA 08/2009 - 11/2008
2	CoumarinsIBA 08/2009 - 11/2008
2	FluoroquinolonesIBA 11/2008 - 01/2008
1	Insulin (Novolin)FDA Link 01/2017
1	Oxygen (Dioxygen)IBA 01/2016
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 09/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2014
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 09/2014
1	NF-kappa B (NF-kB)IBA 05/2014
1	CollagenIBA 05/2014
1	Free RadicalsIBA 05/2014
1	Endothelin Receptor AntagonistsIBA 01/2014
1	Glucose (Dextrose)FDA LinkGeneric 06/2013
1	2- cyano- 3,12- dioxooleana- 1,9(11)- dien- 28- oic acid ethyl amideIBA 06/2013
1	Low Density Lipoprotein Receptor-Related Protein-2IBA 10/2012
1	AlbuminsIBA 10/2012
1	Proteins (Proteins, Gene)FDA Link 10/2012
1	Atropine FDA LinkGeneric 03/2011
1	AllergensIBA 01/2011
1	Ophthalmic Solutions (Eye Drops)IBA 01/2011
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2011
1	OvalbuminIBA 01/2011
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 09/2010
1	Streptozocin (Streptozotocin)FDA Link 08/2009
1	Peroxidase (Myeloperoxidase)IBA 11/2008
1	BOL-303225-AIBA 11/2008
1	IntegrinsIBA 11/2008
1	Lymphocyte Function-Associated Antigen-1 (LFA-1)IBA 11/2008
1	Pharmaceutical PreparationsIBA 11/2008
1	Fibrinolysin FDA Link 06/2008
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 05/2008
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2008
1	Moxifloxacin (Avelox)FDA Link 01/2008
1	Cathepsin KIBA 03/2006
1	relacatibIBA 03/2006
1	AminopeptidasesIBA 09/2005
1	Methionine (L-Methionine)FDA Link 09/2005
1	XenobioticsIBA 06/2004
1	Vasoconstrictor AgentsIBA 11/2002

Therapy/Procedure

2	Oral Administration 01/2019 - 11/2008
2	Radiotherapy 07/2014 - 05/2014
2	Therapeutics 05/2014 - 04/2011
1	Ophthalmic Administration 08/2009
1	Contact Lenses 05/2008